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Antidote for eliquis2/19/2023 ![]() Advise patient to notify health care professional of medication regimen prior to treatment or surgery.Caution patient to notify health care professional if skin rash or signs of severe allergic reaction (chest pain or tightness, swelling of face or tongue, trouble breathing or wheezing, feeling dizzy or faint) occur.Advise patient to notify health care professional immediately if signs of bleeding (unusual bruising, pink or brown urine, red or black, tarry stools, coughing up blood, vomiting blood, pain or swelling in a joint, headache, dizziness, weakness, recurring nose bleeds, unusual bleeding from gums, heavier than normal menstrual bleeding, dyspepsia, abdominal pain, epigastric pain) occurs or if injury occurs, especially head injury. Inform patient that they may bruise and bleed more easily or longer than usual.Advise patient to read Medication Guide before beginning therapy and with each Rx refill in case of changes. If temporarily discontinued, restart as soon as possible. Do not discontinue without consulting health care professional may increase risk of having a stroke, DVT, or PE. Take missed doses as soon as remembered on the same day and resume twice daily administration do not double doses. Instruct patient to take apixaban as directed.May also be suspended in 60 mL of water or D5W and promptly administered through a nasogastric tube. For patients who cannot swallow tablet, 5 mg and 2.5 mg tablets can be crushed, suspended in water, D5W, or apple juice, or mixed with applesauce and administered immediately orally.PO Administer twice daily without regard to food.For surgery , discontinue apixaban at least 48 hrs before invasive or surgical procedures with a moderate or high risk of unacceptable or clinically significant bleeding or at least 24 hrs prior to procedures with a low risk of bleeding or where the bleeding would be non-critical in location and easily controlled.When switching between apixaban and anticoagulants other than warfarin , discontinue one being taken and begin the other at the next scheduled dose.If continuous anticoagulation is necessary, discontinue apixaban and begin both a parenteral anticoagulant and warfarin at time of next dose of apixaban, discontinue parenteral anticoagulant when INR reaches acceptable range. When converting from apixaban to warfarin , apixaban affects INR, so INR measurements may not be useful for determining appropriate dose of warfarin.When converting from warfarin , discontinue warfarin and start apixaban when INR is PO (Adults) : 2.5 mg twice daily after ≥6 mo of treatment of DVT or PE Concurrent use of strong inhibitors of both CYP3A4 and P-gp– Avoid concomitant use. Reduction in Risk of Recurrence of DVT or PE PO (Adults) : 10 mg twice daily for 7 days, then 5 mg twice daily Concurrent use of strong inhibitors of both CYP3A4 and P-gp– 2.5 mg twice daily PO (Adults) : 2.5 mg twice daily, initiated 12–24 hr postoperatively (when hemostasis is achieved) continued for 35 days after hip replacement or 12 days after knee replacement Concurrent use of strong inhibitors of both CYP3A4 and P-gp– Avoid concomitant use. Prevention of Deep Vein Thrombosis Following Knee or Hip Replacement Surgery PO (Adults) : Hemodialysis– 5 mg twice daily HD and either age ≥80 yr or weight ≤60 kg– 2.5 mg twice daily. PO (Adults) : 5 mg twice daily Any 2 of the following: age ≥80 yr, weight ≤60 kg, serum creatinine ≥1.5 mg/dL– 2.5 mg twice daily Concurrent use of strong inhibitors of both CYP3A4 and P-gp– 2.5 mg twice daily if patient already taking 2.5 mg twice daily, avoid concomitant use. Reduction in Risk of Stroke/Systemic Embolism in Nonvalvular Atrial Fibrillation OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk Pedi: Safety and effectiveness not established in children. 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In the next lesson, we'll investigate how to use formatted input and list input to read data into our SAS data sets. And, we'll learn how to create both temporary and permanent SAS data sets. We'll learn how to use column input to read in data values arranged in neatly defined columns. That is, we'll investigate how to read instream data, how to read data from an external raw data file, how to read data from another SAS data set. In this lesson, we'll learn how to tackle all but two of the above situations. the kind of SAS data set that you want to create - Do you want to create a permanent SAS data set? Or do you want to create a temporary SAS data set?.the format of the data - Are the data values arranged in neatly defined columns so that they can be read in using column input? Are the data values separated by at least one blank space so that they can be read in using list input? 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